Endocan and Endothelial Dysfunction

0730. Plasma endocan levels are associated with endothelial dysfunction during experimental human endotoxemia

Introduction The endothelium plays a central role in pathophysiology of sepsis. Systemic inflammation results in endothelial dysfunction, contributing to the development of shock and multiple organ dysfunction. However, an easy to obtain, early, and clinically applicable marker of endothelial dysfunction is currently not available. Such a marker could guide early and targeted therapy such as se...

Immunolocalization of endocan during the endothelial-mesenchymal transition process

Endocan is a dermatan sulfate proteoglycan (DSPG) that has been observed in the cytoplasm of endothelial cells of small and large vessels in lung, kidney, liver, colon, ovary and brain tumors. This DSPG has been implicated in the regulation of cellular activities such as adhesion, migration, and proliferation. Given the important roles played by endocan in such processes, we sought to determi...

Endothelial dysfunction and diabetes.

Endothelial dysfunction and hypertension.

Endothelial Dysfunction and Inflammation